別品名 |
Keramamine A, Manzamine A
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別包装 |
あり
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純度 |
>=98%
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分子量 |
548.76
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CAS RN® |
104196-68-1
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化合物の概要 |
Alkaloid found in marine sponges; vacuolar ATPase uncoupler, GSK3 inhibitor.
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構造 |
C36H44N4O
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使用目的 |
Manzamine A is an alkaloid found in marine sponges. Manzamine A exhibits neuroprotective, anticancer, anti-hyperlipidemic, anti-atherosclerotic, antibiotic, and antiviral activities. In vitro, manzamine A uncouples vacuolar ATPases, inhibiting autophagy and tumor growth. Manzamine A inhibits foam cell formation in macrophages, a hallmark of atherosclerosis. Additionally, manzamine A inhibits cholesterol ester formation and acyl-CoA:cholesterol acyl-transferase (ACAT) activity in vitro and decreases total cholesterol, triglycerides, and LDL levels in vivo. This compound displays antibacterial activity against gram positive and gram negative bacteria; it may also exhibit anti-parasitic activity. In corneal cells, manzamine A inhibits viral replication and infection of herpes simplex virus a (HSV-1), inhibiting HSV-1 virion host shutoff activity. In neuroblastoma cells, manzamine A displays potential benefit in the treatment of Alzheimer’s disease by decreasing tau hyperphosphorylation and inhibiting glycogen synthase kinase 3 (GSK3).
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その他 |
[外観]White Crystal Powder
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参考文献 |
Lin LC, Kuo TT, Chang HY, et al. Manzamine A Exerts Anticancer Activity against Human Colorectal Cancer Cells. Mar Drugs. 2018 Jul 29;16(8):252. doi: 10.3390/md16080252. PMID: 30060617.Guzman EA, Johnson JD, Linley PA, et. al. A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis.Invest New Drugs. 2011 Oct;29(5):777-85. doi: 10.1007/s10637-010-9422-6. Epub 2010 Mar 30. PMID: 20352293Kallifatidis G, Hoepfner D, Jaeg T, et al. The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Mar Drugs. 2013 Sep 17;11(9):3500-16. PMID: 24048269.Eguchi K, Fujiwara Y, Hayashida A, et al. Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo. Bioorg Med Chem. 2013 Jul 1;21(13):3831-8. PMID: 23665143.Aqil F, Zahin M, El Sayed KA, et al. Antimicrobial, antioxidant, and antimutagenic activities of selected marine natural products and tobacco cembranoids. Drug Chem Toxicol. 2011 Apr;34(2):167-79. PMID: 21314466.Palem JR, Bedadala GR, El Sayed KA, et al. Manzamine A as a novel inhibitor of herpes simplex virus type-1 replication in cultured corneal cells. Planta Med. 2011 Jan;77(1):46-51. PMID: 20645244.Hamann M, Alonso D, Martin-Aparicio E, et al. Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease. J Nat Prod. 2007 Sep;70(9):1397-405. PMID: 17708655.Winkler JD, Londregan AT, Hamann MT. Antimalarial activity of a new family of analogues of manzamine A. Org Lett. 2006 Jun 8;8(12):2591-4. PMID: 16737321.
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メーカー |
品番 |
包装 |
LKT
|
M0255
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10 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
-20℃
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