別品名 |
[(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]sulfanyl-(triethyl-λ^{5}-phosphanylidene)gold; Gold, [1-(thio-κS)-β-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-; Gold, (1-thio-β-D-glucopyranosato)(triethylphosphine)-, 2,3,4,6-tetraacetate (8CI); Gold, (1-thio-β-D-glucopyranose 2,3,4,6-tetraacetato-S)(triethylphosphine)-; [1-(Thio-κS)-β-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)gold; β-D-Glucopyranose, 1-thio-, 2,3,4,6-tetraacetate, gold complex; Aktil; Auranofin; Crisinor; Crisofin; NSC 321521; Ridaura; Ridauran; SKF 39162; SKF 39162D; [(Tetra-O-acetyl-β-D-glucopyranosyl)thio](triethylphosphine)gold
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分子量 |
678.48
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CAS RN® |
34031-32-8
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構造 |
C20 H34 Au O9 P S
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溶媒 |
Chloroform (Slightly), Methanol (Slightly)
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使用目的 |
Auranofin is a new oral gold-based antiarthritis drug. Auranofin inhibits various leukocyte activation pathways at multiple sites. Auranofin inhibits the release of inflammatory mediators from human macrophages, basophils, and pulmonary mast cells. Auranofin is an efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions related to its inhibition of mitochondrial thioredoxin reductase.
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その他 |
[融点]104-110℃ [性状]White to Off-White Solid
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参考文献 |
Kizu, R., et al.: Chem. Pharm. Bull., 41, 1261 (1993), Itokazu, M., et al.: Clin. Ther., 17, 60 (1995), Kean, W.F., et al.: Br. J. Rheumatol., 36, 560 (1997),
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メーカー |
品番 |
包装 |
TRC
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A794750
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50 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
2週間程度
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保存温度 |
-20℃
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