別品名 |
3-MA, NSC 66389, NSC66389
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別包装 |
あり
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純度 |
>=98%
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分子量 |
149.15
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CAS RN® |
5142-23-4
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化合物の概要 |
Nucleobase (adenine) analog; DNA polymerase inhibitor.
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構造 |
C6H7N5
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溶媒 |
Water10 mg/mL warmed (67.04 mM)Ethanol4 mg/mL (26.81 mM)DMSO3 mg/mL warmed (20.11 mM)
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使用目的 |
3-Methyl adenine is an autophagy inhibitor that also inhibits DNA polymerase activity and DNA synthesis if incorporated into DNA. Additionally, 3-methyl adenine exhibits antioxidative benefit, decreasing levels of lactate dehydrogenase and ROS/RNS in hydroquinone- and rapamycin-treated cells.
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参考文献 |
Ramirez C, Pham K, Franco MF, et al. Hydroquinone induces oxidative and mitochondrial damage to human retinal Muller cells (MIO-M1). Neurotoxicology. 2013 Dec;39:102-8. PMID: 23994029.Kumar S, Guru SK, Pathania AS, et al. Autophagy triggered by magnolol derivative negatively regulates angiogenesis. Cell Death Dis. 2013 Oct 31;4:e889. PMID: 24176847.Johnson RE, Yu SL, Prakash S, et al. A role for yeast and human translesion synthesis DNA polymerases in promoting replication through 3-methyl adenine. Mol Cell Biol. 2007 Oct;27(20):7198-205. PMID: 17698580.
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メーカー |
品番 |
包装 |
LKT
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M1874
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100 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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