[Pub Med ID]16878026, 17328754, 17339496, 17383753, 18296610, 18607891, 19016710, 19265148, 21179035, 21494799, 21564140, 22792230, 22992740, 23153039, 23868938, 23892030, 24340061, 24512642, 25397678, 26226614＋他多数

[Pub Med ID]18080198, 22792230, 24126516

[Pub Med ID]22815694, 23437263, 24035265, 24372635, 25187624, 25244303, 25280963

1. Meng, G et al; Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes. J Clin Invest 2004, 113: 1473
2. Roura-Mir, C et al; Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2. J Immunol 2005, 175: 1758
3. Leemans, J et al; Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J Clin Invest 2005 115: 2894
4. Spiller, S et al; TLR4-induced IFN-I3 production increases TLR2 sensitivity and drives Gram-negative sepsis in mice. JEM 2008, 205: 1747
5. Sutmuller, R et al; Toll-like receptor 2 controls expansion and function of regulatory T-cells. J Clin Invest 2006, 116:485
6. Brull, F et al; TLR2 activation is essential to induce a Th1 shift in human peripheral blood mononuclear cells by plant stanols and plant sterols. J Biol Chem 2010, 285:2951
7. Guan, Y et al; Human TLRs 10 and 1 share common mechanism of innate immune sensing but not signaling. J Immunol 2010, 184:5094
8. Stribos, E et al; Renal expression of Toll-like receptor 2 and 4: Dynamics in human allograft injury and comparison to rodents. Molecular Immunology 2015, 64: 82
9. Mason, L et al; Borrelia burgdorferi Induces TLR2-Mediated Migration of Activated Dendritic Cells in an Ex Vivo Human Skin Model. PLoS ONE 2016, 11: e0164040
10. Stoppelaar, S et al; Toll-Like Receptor Signalling Is Not Involved in Platelet Response to Streptococcus pneumoniae In Vitro or In Vivo. PLoS ONE 2016, 11: e0156977

[Pub Med ID]24045340

Vogel SN, Fitzgerald KA, and Fenton MJ. (2003) TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 3:466-77. Takeda K, Kaisho T, and Akira S. (2003) Toll-like receptors. Annu. Rev. Immunol. 21:335-76. Janeway CA Jr. and Medzhitov R. (2002) Innate immune recognition. Annu. Rev. Immunol. 20:197-216. O'Neill LAJ, Fitzgerald FA, and Bowie AG. (2003) The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 24:286-9.

1. Flo, T et al; Differential expression of Toll-like receptor 2 in human cells. J Leukoc Biol 2001, 69: 474
2. Schjetne, K et al; Link between innate and adaptive immunity: Toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target. J Immunol 2003, 171: 32
3. Siedlar, M et al; Tolerance induced by the lipopeptide Pam3Cys is due to ablation of IL-1R-associated kinase 1. J Immunol 2004, 173: 2736
4. Tunheim, G et al; Human receptors of innate immunity (CD14, TLR2) are promising targets for novel recombinant immunoglobulin-based vaccine candidates. Vaccine 2007, 25: 4723
5. Burgener, I et al; Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry. Vet Immunol Immunopathol 2008, 124; 184
6. Tehrani, M et al; Decreased levels of soluble Toll-like Receptor 2 in patients with asthma. Reports of Biochemistry & Molecular Biology 2012, 1:30
7. Stribos, E et al; Renal expression of Toll-like receptor 2 and 4: Dynamics in human allograft injury and comparison to rodents. Molecular Immunology 2015, 64: 82

1. Lien, E et al; Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem 1999, 274: 33419
2. Flo, T et al; Differential expression of Toll-like receptor 2 in human cells. J Leukoc Biol 2001, 69: 474
3. Faure, E et al; Bacterial lipopolysaccharide and IFN-I3 induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-IoB activation. J Immunol 2001, 166: 2018
4. Droemann, D et al; Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lung. Histochem Cell Biol 2003, 119: 103
5. Burgener, I et al; Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry. Vet Immunol Immunopathol 2008, 124; 184
6. Elsori, D et al; Protein kinase C is a critical component of Dectin-1 signaling in primary human monocytes. J Leukoc Biol 2011, 90: 599
7. Gaudreault, E et al; TAK1 contributes to the enhanced responsiveness of LTB4-treated neutrophils to Toll-like receptor ligands. Int. Immunol 2012, 24: 693
8. Imamura, Y et al; Salivary histatin 3 inhibits heat shock cognate protein 70-mediated inflammatory cytokine production through toll-like receptors in human gingival fibroblasts. J Inflamm 2014, 11: 4

1. Lien, E et al; Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem 1999, 274: 33419
2. Flo, T et al; Differential expression of Toll-like receptor 2 in human cells. J Leukoc Biol 2001, 69: 474
3. Faure, E et al; Bacterial lipopolysaccharide and IFN-I3 induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-IoB activation. J Immunol 2001, 166: 2018
4. Droemann, D et al; Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lung. Histochem Cell Biol 2003, 119: 103
5. Burgener, I et al; Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry. Vet Immunol Immunopathol 2008, 124; 184
6. Elsori, D et al; Protein kinase C is a critical component of Dectin-1 signaling in primary human monocytes. J Leukoc Biol 2011, 90: 599
7. Gaudreault, E et al; TAK1 contributes to the enhanced responsiveness of LTB4-treated neutrophils to Toll-like receptor ligands. Int. Immunol 2012, 24: 693
8. Imamura, Y et al; Salivary histatin 3 inhibits heat shock cognate protein 70-mediated inflammatory cytokine production through toll-like receptors in human gingival fibroblasts. J Inflamm 2014, 11: 4

1. Meng, G et al; Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes. J Clin Invest 2004, 113: 1473
2. Roura-Mir, C et al; Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2. J Immunol 2005, 175: 1758
3. Leemans, J et al; Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J Clin Invest 2005 115: 2894
4. Spiller, S et al; TLR4-induced IFN-I3 production increases TLR2 sensitivity and drives Gram-negative sepsis in mice. JEM 2008, 205: 1747
5. Sutmuller, R et al; Toll-like receptor 2 controls expansion and function of regulatory T-cells. J Clin Invest 2006, 116:485
6. Brull, F et al; TLR2 activation is essential to induce a Th1 shift in human peripheral blood mononuclear cells by plant stanols and plant sterols. J Biol Chem 2010, 285:2951
7. Guan, Y et al; Human TLRs 10 and 1 share common mechanism of innate immune sensing but not signaling. J Immunol 2010, 184:5094
8. Stribos, E et al; Renal expression of Toll-like receptor 2 and 4: Dynamics in human allograft injury and comparison to rodents. Molecular Immunology 2015, 64: 82
9. Mason, L et al; Borrelia burgdorferi Induces TLR2-Mediated Migration of Activated Dendritic Cells in an Ex Vivo Human Skin Model. PLoS ONE 2016, 11: e0164040
10. Stoppelaar, S et al; Toll-Like Receptor Signalling Is Not Involved in Platelet Response to Streptococcus pneumoniae In Vitro or In Vivo. PLoS ONE 2016, 11: e0156977

1. Meng, G et al; Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes. J Clin Invest 2004, 113: 1473
2. Roura-Mir, C et al; Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2. J Immunol 2005, 175: 1758
3. Leemans, J et al; Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J Clin Invest 2005 115: 2894
4. Spiller, S et al; TLR4-induced IFN-I3 production increases TLR2 sensitivity and drives Gram-negative sepsis in mice. JEM 2008, 205: 1747
5. Sutmuller, R et al; Toll-like receptor 2 controls expansion and function of regulatory T-cells. J Clin Invest 2006, 116:485
6. Brull, F et al; TLR2 activation is essential to induce a Th1 shift in human peripheral blood mononuclear cells by plant stanols and plant sterols. J Biol Chem 2010, 285:2951
7. Guan, Y et al; Human TLRs 10 and 1 share common mechanism of innate immune sensing but not signaling. J Immunol 2010, 184:5094
8. Stribos, E et al; Renal expression of Toll-like receptor 2 and 4: Dynamics in human allograft injury and comparison to rodents. Molecular Immunology 2015, 64: 82
9. Mason, L et al; Borrelia burgdorferi Induces TLR2-Mediated Migration of Activated Dendritic Cells in an Ex Vivo Human Skin Model. PLoS ONE 2016, 11: e0164040
10. Stoppelaar, S et al; Toll-Like Receptor Signalling Is Not Involved in Platelet Response to Streptococcus pneumoniae In Vitro or In Vivo. PLoS ONE 2016, 11: e0156977

Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.
Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.
Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
O'Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.