別包装 |
あり
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純度 |
>=98%
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分子量 |
188.18
|
CAS RN® |
481-42-5
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化合物の概要 |
Naphthoquinone found in Plumbago.
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構造 |
C11H8O3
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使用目的 |
Plumbagin is a naphthoquinone found in a variety of Plumbago species; it exhibits anticancer, anti-inflammatory, antibacterial, and anti-diabetic activities. In cellular models of cancer, plumbagin increases reactive oxygen species production, increases the Bax/Bcl-2 ratio, inhibits activation of NF-κB, and increases caspase activity, inducing apoptosis. In an in vivo model of ulcerative colitis, plumbagin decreases levels of pro-inflammatory cytokines such as TNF-α, IL-17, and IFN-γ, and also decreases colonic monocyte aggregation. This compound also inhibits the assembly and GTPase activity of FtsZ, which plays a significant role in bacterial cell division, inhibiting proliferation in vitro. Additionally, plumbagin inhibits TGF-β1-induced fibronectin and collagen IV expression in vitro and reverses diabetic nephropathy via alterations in Nox4 signaling in diabetic mice.
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その他 |
[外観]Orange Crystals
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参考文献 |
Sagar S, Esau L, Moosa B, et al. Cytotoxicity and Apoptosis Induced by a Plumbagin Derivative in Estrogen Positive MCF-7 Breast Cancer Cells. Anticancer Agents Med Chem. 2013 Oct 21. [Epub ahead of print]. PMID: 24164046.Yong R, Chen XM, Shen S, et al. Plumbagin ameliorates diabetic nephropathy via interruption of pathways that include NOX4 signalling. PLoS One. 2013 Aug 26;8(8):e73428. PMID: 23991195.Qiu JX, He YQ, Wang Y, et al. Plumbagin induces the apoptosis of human tongue carcinoma cells through the mitochondria-mediated pathway. Med Sci Monit Basic Res. 2013 Aug 28;19:228-36. PMID: 23982457.Bhattacharya A, Jindal B, Singh P, et al. Plumbagin inhibits cytokinesis in Bacillus subtilis by inhibiting FtsZ assembly--a mechanistic study of its antibacterial activity. FEBS J. 2013 Sep;280(18):4585-99. PMID: 23841620.Pile JE, Navalta JW, Davis CD, et al. Interventional effects of plumbagin on experimental ulcerative colitis in mice. J Nat Prod. 2013 Jun 28;76(6):1001-6. PMID: 23742275.Xu TP, Shen H, Liu LX, et al. Plumbagin from Plumbago Zeylanica L induces apoptosis in human non-small cell lung cancer cell lines through NF-κB inactivation. Asian Pac J Cancer Prev. 2013;14(4):2325-31. PMID: 23725135.
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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