別品名 |
Periplum, Nimotop, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5- pyridinedicarboxylic acid 2-methoxyethyl 1-methyl- ethyl ester
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別包装 |
あり
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純度 |
>=98%
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分子量 |
418.44
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CAS RN® |
66085-59-4
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化合物の概要 |
L-type Ca2+ channel blocker.
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構造 |
C21H26N2O7
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溶媒 |
Soluble in methanol or DMSO. Insoluble in water.
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使用目的 |
Nimodipine is an antagonist at L-type Ca2+ channels that exhibits antihypertensive, neuroprotective, neuromodulatory, cognition enhancing, and anti-inflammatory activities. In animal models of subarachnoid hemorrhage, nimodipine prevents cerebral ischemia and vasospasm. Nimodipine also inhibits methylmercury-induced behavioral neurotoxicity in vivo. In animal models of Alzheimer’s disease, nimodipine inhibits amyloid-β (Aβ)-stimulated release of IL-1β and resulting neurotoxicity. This compound also inhibits neurological symptoms of drug-induced withdrawal, suppressing anxiety, depression, and memory impairment.
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その他 |
[融点]125℃
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参考文献 |
Bia A GY, Polak P, Michalak A, et al. Influence of calcium channel antagonists on nonsomatic signs of nicotine and d-amphetamine withdrawal in mice. Pharmacol Rep. 2014 Apr;66(2):212-22. PMID: 24911072.Bailey JM, Hutsell BA, Newland MC. Dietary nimodipine delays the onset of methylmercury neurotoxicity in mice. Neurotoxicology. 2013 Jul;37:108-17. PMID: 23583802.Sanz JM, Chiozzi P, Colaianna M, et al. Nimodipine inhibits IL-1β release stimulated by amyloid β from microglia. Br J Pharmacol. 2012 Dec;167(8):1702-11. PMID: 22831460.Sharma N, Cho DH, Kim SY, et al. Magnesium sulfate suppresses L-type calcium currents on the basilar artery smooth muscle cells in rabbits. Neurol Res. 2012 Apr;34(3):291-6. PMID: 22450340.Janjua N, Mayer SA. Cerebral vasospasm after subarachnoid hemorrhage. Curr Opin Crit Care. 2003 Apr;9(2):113-9. PMID: 12657973.
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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