別包装 |
あり
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純度 |
>=98%, TLC, HPLC
|
分子量 |
709
|
CAS RN® |
56092-81-0
|
化合物の概要 |
Polyether Ca2+ ionophore.
|
構造 |
C41H72O9
|
溶媒 |
Soluble in DMSO (10 mg/mL), ethanol (10 mg/mL). Insoluble in water.
|
使用目的 |
Ionomycin is a polyether antibiotic that acts as a Ca2+ ionophore, modulating intracellular Ca2+ signaling to increase cytosolic Ca2+ levels. Ionomycin modulates Ca2+ signaling across many cell types and its depletion of intracellular Ca2+ stores may be linked to the induction of apoptosis.
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参考文献 |
Muller MS, Obel LF, Waagepetersen HS, et al. Complex actions of ionomycin in cultured cerebellar astrocytes affecting both calcium-induced calcium release and store-operated calcium entry. Neurochem Res. 2013 Jun;38(6):1260-5. PMID: 23519933.Dedkova EN, Sigova AA, Zinchenko VP. Mechanism of action of calcium ionophores on intact cells: ionophore-resistant cells. Membr Cell Biol. 2000;13(3):357-68. PMID: 10768486Reynolds JE, Eastman A. Intracellular calcium stores are not required for Bcl-2-mediated protection from apoptosis. J Biol Chem. 1996 Nov 1;271(44):27739-43. PMID: 8910367.Mason MJ, Grinstein S. Ionomycin activates electrogenic Ca2+ influx in rat thymic lymphocytes. Biochem J. 1993 Nov 15;296 ( Pt 1):33-9. PMID: 8250855.
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メーカー |
品番 |
包装 |
LKT
|
I5752
|
5 MG
|
※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
4℃
|
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