別包装 |
あり
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純度 |
>=99%
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分子量 |
164.16
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CAS RN® |
154-17-6
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化合物の概要 |
Glucose metabolism inhibitor, N-linked glycosylation inhibitor.
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構造 |
C6H12O5
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使用目的 |
2-deoxy-D-glucose inhibits glucose metabolism and is used as a biomarker of glucose metabolism, hypoxia, and angiogenesis in a variety of models and cell types, including neurotoxicity, cancer, and autoimmune disease; the 2-OH group of glucose is replaced by a hydrogen and therefore this compound can not be metabolized properly. 2-deoxy-D-glucose inhibits N-linked glycosylation and glycolysis, inhibiting surface expression of MICA/B and other NKG2D ligands on cells. This compound also exhibits anticancer and pro-oxidative activities, increasing oxidative stress and mimicking glucose deprivation, resulting in cell death of cancer cells.
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その他 |
[融点]146-147 ℃
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参考文献 |
Kaira K, Murakami H, Endo M, et al. Biological correlation of (18)F-FDG uptake on PET in pulmonary neuroendocrine tumors. Anticancer Res. 2013 Oct;33(10):4219-28. PMID: 24122985.Andresen L, Skovbakke SL, Persson G, et al. 2-deoxy D-glucose prevents cell surface expression of NKG2D ligands through inhibition of N-linked glycosylation. J Immunol. 2012 Feb 15;188(4):1847-55. PMID: 22227571.Shutt DC, O'Dorisio MS, Aykin-Burns N, et al. 2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells. Cancer Biol Ther. 2010 Jun 1;9(11):853-61. PMID: 20364116.Nowak M, Carrasquillo JA, Yarboro CH, et al. A pilot study of the use of 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography to assess the distribution of activated lymphocytes in patients with systemic lupus erythematosus. Arthritis Rheum. 2004 Apr;50(4):1233-8. PMID: 15077306.Bohmer R, Rommel K. The behaviour of different markers of the mucosal extracellular space in rat small intestine. Acta Hepatogastroenterol (Stuttg). 1975 Dec;22(6):398-403. PMID: 1211066.
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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