別包装 |
あり
|
純度 |
>=98%
|
分子量 |
0.84
|
CAS RN® |
11089-65-9
|
化合物の概要 |
Nucleoside antibiotic mixture; GlcNAc phosphotransferase inhibitor, glycoprotein synthesis inhibitor.
|
構造 |
C40H66N4O16
|
溶媒 |
Soluble in DMSO and DMF.
|
使用目的 |
Tunicamycin is a nucleoside antibiotic mixture that inhibits glycoprotein synthesis. Tunicamycin prevents N-glycosylation by inhibiting GlcNAc phosphotransferase and other enzymes, inducing G1 phase cell cycle arrest in vitro. Tunicamycin displays anti-inflammatory activity, inhibiting toll-like receptor (TLR) activation-induced inflammation by decreasing activation of NF-κB, activity of CRE, and expression of iNOS, COX-2, TNF-α, and IL-1β in macrophages.
|
その他 |
[融点]234℃-235℃ [外観]White Solid
|
参考文献 |
Kim SY, Hwang JS, Han IO. Tunicamycin inhibits Toll-like receptor-activated inflammation in RAW264.7 cells by suppression of NF-κB and c-Jun activity via a mechanism that is independent of ER-stress and N-glycosylation. Eur J Pharmacol. 2013 Dec 5;721(1-3):294-300. PMID: 24056124.Pertusa M, Madrid R, Morenilla-Palao C, et al. N-glycosylation of TRPM8 ion channels modulates temperature sensitivity of cold thermoreceptor neurons. J Biol Chem. 2012 May 25;287(22):18218-29. PMID: 22493431.
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メーカー |
品番 |
包装 |
LKT
|
T8153
|
1 MG
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※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
-20℃
|
|