別品名 |
Sirolimus, Rapamune, AY-22989
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別包装 |
あり
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純度 |
>=98%
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分子量 |
914.17
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CAS RN® |
53123-88-9
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化合物の概要 |
Macrolide originally produced by Streptomyces; mTOR inhibitor.
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構造 |
C51H79NO13
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溶媒 |
Soluble in ether, chloroform, acetone, methanol, DMF, DMSO (20 mg/mL), and ethanol (up to 2 mM). Sparingly soluble in hexane and petr ether. Insoluble in water.
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使用目的 |
Rapamycin is a macrolide initially produced by Streptomyces that exhibits immunosuppressive and pro-fibrotic activities. Rapamycin inhibits mTOR by binding FKBP12 and forming a complex that binds directly to mTOR; it is clinically used to prevent rejection in organ transplant patients. Rapamycin prevents IL-2-induced activation of T cells and B cells. Rapamycin also prevents IgA nephropathy, decreasing IgA deposition, inhibiting cell proliferation, and suppressing expression of α-SMA, type III collagen, PDGF, and TGF-β1. Additionally, rapamycin increases connective tissue growth factor levels in epithelial cells.
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その他 |
[融点]183℃-185℃ [外観]White Crystal Powder
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参考文献 |
Klintmalm GB, Nashan B. The Role of mTOR Inhibitors in Liver Transplantation: Reviewing the Evidence. J Transplant. 2014;2014:845438. PMID: 24719752.Tian J, Wang Y, Zhou X, et al. Rapamycin slows IgA nephropathy progression in the rat. Am J Nephrol. 2014;39(3):218-29. PMID: 24603476.Xu X, Wan X, Geng J, et al. Rapamycin regulates connective tissue growth factor expression of lung epithelial cells via phosphoinositide 3-kinase. Exp Biol Med (Maywood). 2013 Sep;238(9):1082-94. PMID: 23986222.
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メーカー |
品番 |
包装 |
LKT
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R0161
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25 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
4℃
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