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メーカー名称:LKT Laboratories, Inc.
(+)-Catechin
メーカー 品番 包装 希望販売価格 在庫 別包装/
セット品
販売状況
LKT
メーカー正式名称
LKT Laboratories, Inc.
C0278 5MG ¥26,000
/
 
別名 Catechol; Catechinic acid; Dexcyanidanol; Cyanidol; Catergen, (2R-trans)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H- 1-benzopyran-3,5,7-triol
納期目安 1週間程度
法規制 -
保存温度 マイナス20℃
カテゴリ 化成品

内容:
種由来:-
純度 :>=99%
分子量 :290.27
CAS RN®: 154-23-4
阻害剤の対象:Flavanol originally found in Camilla (green tea); MAO-B inhibitor.

使用目的: Catechin is a flavanol originally found in Camilla and other plant sources; it exhibits antioxidative, anti-aging, anti-atherosclerotic, anti-ulcerative, neuroprotective, neuromodulatory, anticancer chemotherapeutic, and chemopreventive activities. Catechin increases life span in Caenorhabditis elegans and inhibits monoamine oxidase B (MAO-B) in vitro. Catechin decreases atherosclerotic lesion area, suppresses leukocyte adhesion, and inhibits LDL oxidation and uptake in animal models of atherosclerosis. In animal models of brain hemorrhage, catechin increasers activity of Nrf2 and phase II detoxifying enzymes, inhibiting oxidative stress, neurological deficits, and lesion formation. In other animal models, catechin inhibits histidine decarboxylase, decreasing gastric lesion formation. Additionally, catechin increases muscle fatigue resistance and exercise capacity in vivo. This compound also decreases tumor number and formation and suppresses phosphorylation of FAK in animal models of colorectal cancer.
構成内容: -
構造: C15H14O6
その他: [溶解性]Soluble in hot water, alcohol acetone, and glacial acetic acid.
[融点]93℃-96℃
[外観]Faintly brown powder
参考文献: Chang CF, Cho S, Wang J. (-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways. Ann Clin Transl Neurol. 2014 Apr 1;1(4):258-271. PMID: 24741667.Nogueira L, Ramirez-Sanchez I, Perkins GA, et al. (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15;589(Pt 18):4615-31. PMID: 21788351.Saul N, Pietsch K, Menzel R, et al. Catechin induced longevity in C. elegans: from key regulator genes to disposable soma. Mech Ageing Dev. 2009 Aug;130(8):477-86. PMID: 19501612.Auclair S, Milenkovic D, Besson C, et al. Catechin reduces atherosclerotic lesion development in apo E-deficient mice: a transcriptomic study. Atherosclerosis. 2009 Jun;204(2):e21-7. PMID: 19152914.Hou WC, Lin RD, Chen CT, et al. Monoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophylla. J Ethnopharmacol. 2005 Aug 22;100(1-2):216-20. PMID: 15890481.Weyant MJ, Carothers AM, Dannenberg AJ, et al. (+)-Catechin inhibits intestinal tumor formation and suppresses focal adhesion kinase activation in the min/+ mouse. Cancer Res. 2001 Jan 1;61(1):118-25. PMID: 11196148.Mangiapane H, Thomson J, Salter A, et al. The inhibition of the oxidation of low density lipoprotein by (+)-catechin, a naturally occurring flavonoid. Biochem Pharmacol. 1992 Feb 4;43(3):445-50. PMID: 1540202.Reimann HJ, Lorenz W, Fischer M, et al. Histamine and acute haemorrhagic lesions in rat gastric mucosa: prevention of stress ulcer formation by (+)-catechin, an inhibitor of specific histidine decarboxylase in vitro. Agents Actions. 1977 Mar;7(1):69-73. PMID: 871094.

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