別品名 |
Biston, Carbatrol, Epitol, Sirtal, Telesmin, Timonil, 5H-Dibenz[b,f]azepine-5-carboxamide
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別包装 |
あり
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純度 |
>=98%
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分子量 |
236.27
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CAS RN® |
298-46-4
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化合物の概要 |
GABA potentiator, voltage-gated Na+ and ATP-sensitive K+ channel blocker.
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構造 |
C15H12N2O
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溶媒 |
Soluble in alcohol, acetone or propylene glycol. Practically insoluble in water.
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使用目的 |
Carbamazepine is an antiepileptic/anticonvulsant that also exhibits antipsychotic and anti-inflammatory activities. Carbamazepine inhibits voltage-gated Na+ channels, stabilizing the inactive conformation of the channel. Carbamazepine also potentiates GABA receptor signaling and inhibits ATP-sensitive K+ channels. Carbamazepine is clinically used to treat epilepsy, bipolar disorder, neuralgia/neuropathic pain, ADHD, schizophrenia, and post-traumatic stress disorder (PTSD). In animal models, carbamazepine decreases LPS-induced expression of TNF-α and IL-1β.
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その他 |
[融点]190℃-193℃
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参考文献 |
Gomez CD, Buijs RM, Sitges M. The anti-seizure drugs vinpocetine and carbamazepine, but not valproic acid, reduce inflammatory IL-1β and TNF-α expression in rat hippocampus. J Neurochem. 2014 Jun 5. [Epub ahead of print]. PMID: 24903676.Zhou Q, Chen PC, Devaraneni PK, et al. Carbamazepine inhibits ATP-sensitive potassium channel activity by disrupting channel response to MgADP. Channels (Austin). 2014 May 21;8(4). [Epub ahead of print]. PMID: 24849284.Rahman W, Dickenson AH. Voltage gated sodium and calcium channel blockers for the treatment of chronic inflammatory pain. Neurosci Lett. 2013 Dec 17;557 Pt A:19-26. PMID: 23941888.Bialer M. Why are antiepileptic drugs used for nonepileptic conditions? Epilepsia. 2012 Dec;53 Suppl 7:26-33. PMID: 23153207.
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
4℃
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